1-(3-Chlorophenyl)piperazine



1-(3-Chlorophenyl)piperazine
Systematic (IUPAC) name
1-(3-Chlorophenyl)piperazine
Identifiers
CAS number 6640-24-0
ATC code  ?
PubChem 1355
Chemical data
N2 
Mol. mass 196.676 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic
Half life  ?
Excretion renal
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes oral

 

1-(3-Chlorophenyl)piperazine (or meta-chlorophenylpiperazine, mCPP) is a stimulants in New Zealand, and pills sold as ecstasy in Europe and the United States.

mCPP is known to induce headaches in humans,[1][2] and has been used for testing potential anti-migraine medications.[3] Up to 10% of people who take mCPP will develop a migraine headache, and 90% of individuals who commonly suffer from migraines will have an attack induced by mCPP. This has tended to limit the use of mCPP as a recreational drug.

Legal status

In the US: unscheduled
In New Zealand: unscheduled
In Denmark: Banned [4]
In Germany: Banned

See also

References

  1. ^ Leone, M; A Attanasio, D Croci, G Filippini, D D'Amico, L Grazzi, A Nespolo, G Bussone (July 12 2000). "The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study". Neurology 55 (1): 136-9. PMID 10891925.
  2. ^ Martin RS & Martin GR. Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC). Cephalalgia 2001; 21:46–52. London. ISSN 0333-10245
  3. ^ Petkov VD, Belcheva S, Konstantinova E. Anxiolytic effects of dotarizine, a possible antimigraine drug. Methods Find Exp Clin Pharmacol. 1995 Dec;17(10):659-68.
  4. ^ Erowid.org
 
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