18-Methoxycoronaridine



18-Methoxycoronaridine
Systematic (IUPAC) name
(-)-18-methoxycoronaridine
Identifiers
CAS number 308123-60-6
ATC code  ?
PubChem 10248465
Chemical data
O3 
Mol. mass 368.47 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

(-)-18-Methoxycoronaridine (18-MC) is a derivative of serotonin transporter.[2] 18-MC has not yet been tested in humans. In 2002 the research team started trying to raise funds for human trials, but were unable to secure the estimated $5 million needed.[3] Efforts to raise funds for future trials are still ongoing.[1]

Its CAS number is [308123-60-6] for the free base and [266686-77-5] for the monohydrochloride.

References

  1. ^ S.D. Glick (1996). "18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats". Brain Res. 719 (1-2): 29-35. PMID 8782860.
  2. ^ I.M. Maisonneuve (2003). "Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment". Pharmacol. Biochem. Behav. 75 (3): 607-18. PMID 12895678.
  3. ^ Addiction Treatment Strives for Legitimacy. Journal of the American Medical Association. 2002; 288: 3096-3101.

Further reading

  1. S.D. Glick (2006). "18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats". Eur. J. Pharmacol.. PMID 16626688.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "18-Methoxycoronaridine". A list of authors is available in Wikipedia.