ALD-52

ALD-52 or N-acetyl-LSD, is a chemical analogue of Albert Hofmann but was not widely studied until the rise in popularity of psychedelics in the 1960s.

Effects

In TiHKAL, Shulgin touches briefly on ALD-52 in entry 26, LSD. His writings are vague, second hand accounts, saying doses in the 50-175µg range have resulted in various conclusions. One found that there was less visual distortion than with LSD and it seems to produce less anxiety and was somewhat less potent than LSD. Another report claimed it was more effective in increasing blood pressure. Yet another could not tell them apart.

It has the same characteristics as LSD, but supposedly "without the anxiety, tenseness, and other problems inherent to it".

Dangers

In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 (D,L-Acetyllysergic acid diethylamide) is listed as having a lower (approximately ¹/₅) intravenous toxicity (in rabbits), a lower (approximately ¹/₈) pyretogenic effect, an equal psychological effect in man, and double the antiserotonin effect as compared with LSD.

History

It is possible ALD-52 was the active chemical in the "Orange Sunshine" hydrolysis to LSD, and second, the synthesis of ALD-52 required LSD (this was based on the methods available in the scientific literature at the time). Scully was convicted and served time in prison.

Sources

• Entry #26 from TiHKAL
• everything2
• Totse
• Lycaeum
• White Light