Angiotensin receptor

angiotensin II receptor, type 1
Identifiers
Symbol	AGTR1
Alt. Symbols	AGTR1B
Entrez	185
HUGO	336
OMIM	106165
RefSeq	NM_000685
UniProt	P30556
Other data
Locus	Chr. 3 q21-q25

angiotensin II receptor, type 2
Identifiers
Symbol	AGTR2
Entrez	186
HUGO	338
OMIM	300034
RefSeq	NM_000686
UniProt	P50052
Other data
Locus	Chr. X q22-q23

The angiotensin receptors are a class of signal transduction of the main effector hormone.^[2]

Structure

The AT₁ and AT₂ receptors share a sequence identity of ~30%, but have a similar affinity for angiotensin II, which is their main ligand.

Members

Overview table

Receptor	Mechanism ^[3]
AT₁	G_q/11 G_i/o
AT₂	G_i2 / ₃
AT₃
AT₄

AT₁

Main article: Angiotensin II receptor type 1

The AT₁ receptor is the best elucidated angiotensin receptor.

Mechanism

It is activated by angiotensin II. It is coupled to G_q/11 and G_i/o and thus activates phospholipase C and increases the cytosolic Ca²⁺ level, which itself performs cellular mechanisms, as well as activating adenylate cyclase and activate various tyrosine kinases.^[2]

Effects

Effects mediated by the AT₁ receptor include vasoconstriction, sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.^[4]

AT₂

AT₂ receptors are more plentiful in the fetus and neonate. Effects mediated by the AT₂ receptor include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, vasodilation.

AT₃ and AT₄

Other poorly characterized subtypes include the AT₃ and AT₄ receptors. The AT₄ receptor is activated by the angiotensin II metabolite angiotensin IV, and may play a role in regulation of the CNS extracellular matrix.

References

^ de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000). "International union of pharmacology. XXIII. The angiotensin II receptors". Pharmacol. Rev. 52 (3): 415–72. PMID 10977869.
^ ^a ^b Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin. Sci. 112 (8): 417–28. doi:10.1042/CS20060342. PMID 17346243.
^ Unless else specified in box, then ref is: Senselab
^ Catt KJ, Mendelsohn FA, Millan MA, Aguilera G (1984). "The role of angiotensin II receptors in vascular regulation". J. Cardiovasc. Pharmacol. 6 Suppl 4: S575–86. PMID 6083400.

v • d • e Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

v • d • e Nociceptin
Other neuropeptide receptors	Angiotensin - Bradykinin (B1, B2) / Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin

Categories: G protein coupled receptors

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Angiotensin_receptor". A list of authors is available in Wikipedia.