Betaxolol



Betaxolol
Systematic (IUPAC) name
1-[4-[2-(cyclopropylmethoxy)
ethyl]phenoxy]-3-
(1-methylethylamino)propan-2-ol
Identifiers
CAS number 63659-18-7
ATC code S01ED02
PubChem 2369
DrugBank APRD00245
Chemical data
O3 
mol
Pharmacokinetic data
Bioavailability 89%
Metabolism Hepatic
Half life 14-22hours
Excretion Renal (20%)
Therapeutic considerations
Pregnancy cat.

C(AU) C(US)

Legal status

℞ Prescription only

Routes oral, ocular

Betaxolol (trade names Betoptic, Betoptic S, Lokren) is a selective metoprolol. In addition to its effect on the heart, betaxolol reduces the pressure within the eye (intraocular pressure). This effect is thought to be caused by reducing the production of the liquid (which is called the aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma.

Betaxolol was approved by the U.S. Food and Drug Administration (FDA) for ocular use as a 0.5% solution (Betoptic) in 1985 and as a 0.25% solution (Betoptic S) in 1989.

See also

Levobetaxolol

v • d • e
Labetalol
v • d • e
Ophthalmologicals: antiglaucoma preparations and miotics (Dapiprazole • Guanethidine
 
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