Mechlorethamine



Mechlorethamine
Systematic (IUPAC) name
2-chloro-N-(2-chloroethyl)-N-methyl-ethanamine
Identifiers
CAS number 51-75-2
ATC code L01AA05
PubChem 4033
DrugBank APRD00249
Chemical data
N 
Mol. mass 156.055 g mol−1
Pharmacokinetic data
Bioavailability  ?
Metabolism Rapid hydrolysis and demethylation, possibly in plasma
Half life < 1 minute
Excretion Urine (50% as metabolites, <0.01% as unchanged drug)
Therapeutic considerations
Pregnancy cat.

D (US)

Legal status

℞ Prescription only

Routes IV, intracavitary, intrapericardially, topical

Mechlorethamine also known as chlormethine, mustine, nitrogen mustard and HN2 and sold under the brand name Mustargen, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of alkylating agents.

It has been combined with estrogen as estramustine, used to treat prostate cancer.

It can also be used in vesicant.

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