Chemokine receptor

Structural characteristics

Chemokine receptors are G-proteins couple to the C-terminal end, which is important for receptor signaling following ligand binding. Although chemokine receptors share high amino acid identity in their primary sequences, they typically bind a limited number of ligands.^[3]

Signal Transduction

For more details on this topic, see G protein.

integrins.^[3]

Families

• CXC chemokine receptors (seven members)

• CC chemokine receptors (ten/eleven members)

• C chemokine receptors (one member, XCR1)

• CX₃C chemokine receptors (one member, CX3CR1)

References

1. ^ Murphy PM, Baggiolini M, Charo IF, Hébert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA (2000). "International union of pharmacology. XXII. Nomenclature for chemokine receptors". Pharmacol. Rev. 52 (1): 145–76. PMID 10699158.
2. ^ Murphy PM (2002). "International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature". Pharmacol. Rev. 54 (2): 227–9. doi:10.1124/pr.54.2.227. PMID 12037138.
3. ^ ^{a b} Murdoch C, Finn A (2000). "Chemokine receptors and their role in inflammation and infectious diseases". Blood 95 (10): 3032–43. PMID 10807766.