Combined hyperlipidemia

In medicine, combined hyperlipidemia (or -aemia) is a commonly occurring form of hyperlipoproteinemia type IIB.

The elevated lipoprotein that is prone to cause atherosclerosis.

Types

There are roughly two forms of this lipid disorder:

• Familial combined hyperlipidemia (FCH) is the familiar occurrence of this disorder, probably caused by polymorphisms in molecules and cholesterylester transferring protein).
• Acquired combined hyperlipidemia is extremely common in patients who suffer from other diseases from the VLDL synthesis by the liver. Initially, most VLDL is converted into LDL until this mechanism is saturated, after which VLDL levels elevate.

Treatment

Both conditions are treated with peroxisome proliferator-activated receptors (PPARs), specifically PPARα, to decrease free fatty acid production.

rosuvastatin) can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor expression.