Dextrorphan

Dextrorphan (DXO) is a pharmacologically active metabolite of dextromethorphan (DXM).

Chemistry

It is the result of O-demethylation of the CYP2D6) pathway.

Pharmacology

Dextrorphan is structurally similar to NMDA receptor antagonist, dextrorphan is a more potent antagonist[1].

It should be noted, however, that due to its potency as an NMDA receptor antagonist, as well as the fact that it is produced as a by-product of DXM metabolization in the body, DXO is thought to be largely responsible for the psychological side-effects that occur at high doses of DXM. These side-effects can include alteration of consciousness, or "cognitive dissociation", which are characteristic of NMDA blockade and which have afforded DXM its potential for use as a recreational drug.

See also

• Levorphanol
• Dextromethorphan
• Ketamine (compound that acts most similarly to dextrorphan)
• Hallucinogen
• Psychedelic
• Racemethorphan
• Morphinans