Dopamine reuptake inhibitor



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Dopamine Reuptake Inhibitors (DARI), Dopamine Uptake Inhibitors, Dopamine Transporter Inhibitors are compounds that inhibit the Nicotine also acts as a dopamine reuptake inhibitor, albeit a weaker one. Side effects from these drugs can be mixed. In some they induce euphoria, and in others they may induce restlessness and irritability; not unlike cocaine users.

Mechanism

DARIs bind at the transporter molecule and form a non-covalent complex with it.[citation needed] When the DARI-molecule is large enough, which is normally the case, it suppresses the binding of other substances that are transporter substrates, such as endogenous compounds (like dopamine) and drugs (e.g. amphetamine).[citation needed]

Types

vanoxerine).

Abuse

In general, the abuse potential of DAR inhibitors depends on how they affect the pattern of dopamine release and reuptake.

Compounds that inhibit reuptake and also induce release of dopamine, such as methamphetamine or methylphenidate, tend to be addictive drugs with potential for abuse in humans.[citation needed]

On the other hand, compounds that inhibit reuptake but also inhibit release of dopamine, such as vanoxerine, have mild stimulant effects and little abuse potential, and can be used to treat stimulant addiction.[citation needed]

Some dopamine reuptake inhibitors

See also

Further reading

  • Runyon SP, Carroll FI (2006). "Dopamine transporter ligands: recent developments and therapeutic potential". Current topics in medicinal chemistry 6 (17): 1825-43. PMID 17017960.

References

  1. ^ Heal DJ, Frankland AT, Gosden J, et al (1992). "A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine". Psychopharmacology (Berl.) 107 (2-3): 303-9. PMID 1615130.
v • d • e
Psychoanaleptics: RIs
S RI Trazodone)
A RI Maprotiline)
D RI Amineptine)
SN RI Venlafaxine
ND RI Bupropion
SND RI Nomifensine
Mirtazapine)
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NMDA antagonist
 
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