Gliotoxin



Gliotoxin
Molecular formula C13H14N2O4S2
Identifiers
CAS number 67-99-2
SMILES O=C1N(C)C2(CO)C(N(C3C(C4)=CC=C[C@@H]3O)C41SS2)=O
Properties
Molar mass 326.4 g/mol
Appearance white to light yellow solid
Solubility in DMSO soluble
Hazards
MSDS MSDS from Fermentek
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Gliotoxin is a yeast Candida. It was originally isolated from Gliocladium fimbriatum, and was named accordingly. It is an epipolythiodioxopiperazine metabilite.

Gliotoxin possesses immunosuppressive properties as it may suppress and cause thiol groups in the cell membranes.

References

  1. ^ [1]
  • Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro: A. Müllbacher, et al.; J. Gen. Microbiol. 131, 1251 (1985)
  • "Mechanism of gliotoxin action and factors mediating gliotoxin sensitivity". R.W. Jones & J.G. Hancock; J. Gen. Microbiol. 134: 2067-2075 (1988)
  • Gliotoxin stimulates Ca2+ release from intact rat liver mitochondria: M. Schweizer & C. Richter; Biochemistry 33, 13401 (1994)
  • Extracellular calcium is not required for gliotoxin or dexamethasone- induced DNA fragmentation: a reappraisal of the use of EGTA: P. Waring & A. Sjaarda; Int. J. Immunopharmacol. 17, 403 (1995)
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gliotoxin". A list of authors is available in Wikipedia.