Gp41



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HIV gp41
HIV gp41
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gp41 is a conformation causing gp41 to become exposed, where it can assist in fusion with the host cell.

enfuvirtide block the fusion process by binding to gp41.

The env gene does not actually code for gp120 and gp41, but for a precursor to both, gp160. During HIV reproduction, the host cell's own enzymes cleave gp160 into gp120 and gp41. See Replication cycle of HIV.

A polyclonal caprine antibody is in phase II human clinical trials that targets among others sites, the GP41 transmembrane glycoprotein. This is a new class of treatment for HIV infection. The trials are being conducted for for a patented biologic developed by Virionyx, as New Zealand Company. [1]

See also

  • HIV structure and genome

References

  1. ^ virionyx.com. Retrieved on 2007-08-26.
 
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