Guanine nucleotide exchange factor

Guanine nucleotide exchange factor (or guanine exchange protein) (GEFs) is implicated in addressing system of vesicular transport. For example, SNARE protein interactions.

Examples of GEFs

• MAPK/ERK pathway.

• eIF-2b - The eukaryotic initiation factor 2b regenerates eIF-2a for an additional cycle in protein synthesis initiation, i.e. its binding to the Met-t-RNA.

• Ras-GRF1

• G proteins.

• Kalirin

See also

• nucleotide exchange factor
• guanine