Ifosfamide



Ifosfamide
Systematic (IUPAC) name
3-(2-chloroethyl)-2
-[(2-chloroethyl)amino]tetrahydro
-2H-1,3,2-oxazaphosphorine 2-oxide
Identifiers
CAS number 3778-73-2
ATC code L01AA06
PubChem 3690
DrugBank APRD00007
Chemical data
P 
Mol. mass 261.1
Pharmacokinetic data
Bioavailability 100%
Metabolism Hepatic
Half life 60-80% in 72 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status

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Routes intravenously

Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a intravenous, and is given as a treatment for a variety of cancers, including:

  • Testicular cancer
  • Breast cancer
  • Lymphoma (Non-Hodgkin)
  • Soft tissue sarcoma
  • Osteogenic sarcoma
  • Lung cancer
  • Cervical cancer
  • Ovarian cancer
  • Bone cancer

Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.

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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ifosfamide". A list of authors is available in Wikipedia.