Lansoprazole



Lansoprazole
Systematic (IUPAC) name
2-[(3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl) methylsulfinyl] -1H-benzoimidazole
Identifiers
CAS number	103577-45-3
ATC code	A02BC03
PubChem	3883
DrugBank	APRD00077
Chemical data
S
Mol. mass	369.363 g/mol
Pharmacokinetic data
Bioavailability	80% or more
Protein binding	97%
CYP2C19-mediated)
Half life	1–1.5 hours
Excretion	Renal and fecal
Therapeutic considerations
Licence data	US
Pregnancy cat.	B3(AU) B(US)
Legal status	℞ Prescription only
Routes	Oral, IV

Lansoprazole (lan-SOE-pra-zole, TAP Pharmaceutical Products.

Pharmacology

Lansoprazole is a omeprazole. Lansoprazole has been marketed for many years and is one of several PPI's available.^{[citation needed]}

Lansoprazole's plasma elimination half-life is not proportional to the duration of the drug's effects (i.e. gastric acid suppression). The mean plasma elimination half-life is 1.5 hours,^[1] and the effects of the drug last for over 24 hours after it has been used for 1 day or more.^{[citation needed]}

Prevacid is now manufactured and distributed by Novartis Consumer Health.

Indications

Lansoprazole is indicated for:

Treatment of ulcers of the stomach and duodenum, and NSAID-induced ulcers
Treatment of gastroesophageal reflux disease (GERD) (also known as acid reflux disease)
Treatment of Zollinger-Ellison Syndrome
Adjunctive treatment of antibiotics

Contraindications

PPI’s reduce absorption of Digoxin in plasma
Increases plasma concentrations of Cilostazol (risk of toxicity)
Absorption of lansoprazole possibly reduced by:
sucralfate
ampicillin
bisacodyl
delavirdine
fluvoxamine
iron salts
theophylline
voriconazole
theophylline
astemizole

Side effects

Infrequent: dry mouth, insomnia, drowsiness, blurred vision, rash, pruritus
Rarely and very rarely: taste disturbance, liver dysfunction, peripheral oedema, hypersensitivity reactions (including bronchospasm, urinary, angioedema, anaphylaxis), photosensitivity, fever, sweating, depression, interstitial nephritis, blood disorders (including leukopenia, leukocytosis, pancytopenia, thrombocytopenia), arthralgia, myalgia, skin reactions (including Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous eruption)
Severe: Gastro-intestinal disturbances (such as nausea 1.3%, abdominal pain 2.1%, diarrhea 3.8%^[1]

Brand names

The drug is sold with the following brand names:

Aprazol (Turkey)
Lansox (Italy)
Limpidex (Italy)
Prevacid (U.S. and Canada)
Takepron (Japan)
Zoton (Italy, Australia, UK)
Refluxon (Hungary)
Duogast (Syria)
Lanzap
Prosogan
Lanton (Israel)
Ogast (France)
SOLOX (New Zealand)
Prosogan FD (Indonesia)

Lansoprazole is also available as a generic drug in Belgium, Colombia, Italy and Mexico.

References

^ ^a ^b Prevacid Pharmacology, Pharmacokinetics, Studies, Metabolism. RxList.com (2007). Retrieved on 2007-04-14.

v • d • e
Drugs for acid related disorders: Drugs for peptic ulcer and GERD/GORD (Pirenzepine

Proton pump inhibitors

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Lansoprazole". A list of authors is available in Wikipedia.