List of recombinant proteins



Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature

Human recombinants that replaced animal or harvested from human types

  • Serono replaced cadaver harvested human growth hormone
  • Lilly replaced bovine and porcine insulin for human therapy
  • Serono's Pergonal which was previously isolated from post-menopausal female urine
  • Bayer replaced blood harvested factor VIII

Human recombinants with recombination as only source

  • Amgen
  • Granulocyte colony-stimulating factor (G-CSF) filgrastim sold as Neupogen® from Amgen; pegfilgrastim sold as Neulasta®
  • alpha-glactosidase A Fabrazyme® by Genzyme
  • alpha-L-iduronidase (rhIDU; laronidase) Aldurazyme® by BioMarin Pharmaceutical and Genzyme
  • N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase) Naglazyme (TM) by BioMarin Pharmaceutical
  • DNAse Pulmozyme® by Genentech
  • Tissue plasminogen activator (TPA) Activase® by Genentech
  • Glucocerebrosidase Ceredase® by Genzyme
  • Interferon (IF) Interferon-beta-1a as Rebif® from Schering
  • Insulin-like growth factor 1 (IGF-1)

Animal recombinants

Viral recombinants
 
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