Methysergide



Methysergide
Systematic (IUPAC) name
1-Methyl-d-lysergic acid-(1-hydroxybut-2-yl)amide
Identifiers
CAS number 361-37-5
ATC code N02CA04
PubChem 9681
DrugBank APRD00463
Chemical data
O2 
Mol. mass 353.458 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Methysergide (UML-491) is a prescription drug used for prophylaxis of migraine headaches and is sold under the brand names Sansert and Deseril in 2mg dosages. Methysergide was approved by the receptor antagonist for the 5-HT receptor 2C[1].

Methysergide is one of the most effective medications for the prevention of migraine, but not for the treatment of an acute attack. It has a known Sandoz, but currently lists it as a product.

Like LSD, methysergide also produces psychedelic and hallucinogenic effects above a dosage of about 4mg.[3] Full effects are felt with dosages of 8-20mg.[citation needed]

See also

Triptan

References

  1. ^ Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 187
  2. ^ emedicine.com (2002)
  3. ^ L. Bender (1970): "Children's Reactions to Psychotomimetic Drugs", Psychotomimetic Drugs, pp. 265-273]
 
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