2-Oxazolidone



2-Oxazolidone
IUPAC name 1,3-Oxazolidin-2-one
Other names 2-Oxazolidone
2-Oxazolidinone
Identifiers
CAS number 497-25-6
SMILES O=C1NCCO1
Properties
Molecular formula C3H5NO2
Molar mass 87.077 g/mol
Appearance Solid
Melting point

86 - 89 °C

Boiling point

220 °C at 48 torr

Solubility in water  ? g/100 ml (?°C)
Hazards
Flash point  ?°C
Related Compounds
Related compounds Oxazolidine
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

2-Oxazolidone is a organic compound containing both nitrogen and oxygen in a 5-membered ring.

Oxazolidinones

Evans auxiliaries

Oxazolidinones are a class of compounds containing 2-oxazolidone in the structure. In chemistry, they are useful as imide. Substituents at the 4 and 5 position of the oxazolidinone direct any aldol reaction to the alpha position of the carbonyl of the substrate.

Pharmaceuticals

Oxazolidinones are used as antibiotics. Some of the most important oxazolidinones are the last generation of antibiotics used against gram-positive pathogens, including superbugs such as Methicillin-resistant Staphylococcus aureus. Developed during the nineties when several bacterial strains were becoming resistant against such antibiotics as bioavailability.

  The first commercially available oxazolidinone antibiotic was rivaroxaban, an oxazolidinone derivative, is undergoing trials.

References
     
    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2-Oxazolidone". A list of authors is available in Wikipedia.