Pergolide



Pergolide
Systematic (IUPAC) name
 ?
Identifiers
CAS number 66104-22-1
ATC code N04BC02
PubChem 47811
DrugBank APRD00663
Chemical data
S 
Mol. mass 314.489 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 90%
Metabolism Extensively hepatic
Half life 27 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B

Legal status

Withdrawn (U.S.)

Routes Oral

Pergolide is an ergoline-based agonist used for the treatment of Parkinson's disease.

Parkinson's disease is associated with low levels of the dopamine in the brain. Pergolide has some of the same effects as dopamine in the body.

Uses

Pergolide is also used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease, although it has also been used to treat discomfort or pain in the lower extremities that can only be relieved by moving the legs. Pergolide is often used in conjunction with other medicines in the treatment of Parkinson's disease.

Furthermore, pergolide may also be used for veterinary purposes. It is commonly used for the treatment of pituitary pars intermedia hyperplasia or Equine Cushing's Syndrome (ECS) in horses. [1]

Side effects

The drug is in decreasing use, as it was reported in 2003 to be associated with a form of heart disease called cardiac fibrosis.[2] This problem is thought to be due to pergolide's action at the 5-HT2B serotonin receptors of cardiac myocytes, causing proliferative valve disease by the same mechanism as cabergoline (Dostinex) was reported also to be associated with valvular proliferation heart damage.[4] In March 2007, pergolide was withdrawn from the U.S. market due to serious valvular damage that was shown in two independent studies.[5]

Pergolide has also been shown to impair associative learning.[6]

On March 30th, 2007, manufacturers of Pergolide agreed to withdraw the drug from the U.S. market after several published studies revealed a link between the drug and increased rates of valvular dysfunction. [7]

References

  1. ^ Barbara Forney, VMD. Pergolide For Veterinary Use.
  2. ^ ADRAC (August 2004). "Cardiac valvulopathy with pergolide". Aust Adv Drug React Bull 23 (4). Free full text from the Australian Therapeutic Goods Administration
  3. ^ Jähnichen S, Horowski R, Pertz H. "Pergolide and Cabergoline But not Lisuride Exhibit Agonist Efficacy at Serotonin 5-HT2B Receptors".PDF (515 KiB) Presentation. Retrieved on 2007-03-30.
  4. ^ Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E (2007). "Dopamine agonists and the risk of cardiac-valve regurgitation". N Engl J Med 356 (1): 29–38. PMID 17202453.
  5. ^ MedWatch - 2007 Safety Information Alerts. Permax (pergolide) and generic equivalents. U.S. Food and Drug Administration (March 29, 2007). Retrieved on 2007-03-30.
  6. ^ Breitenstein C et al. (2006). "Tonic dopaminergic stimulation impairs associative learning in healthy subjects". Neuropsychopharmacology 31 (11): 2552–64. doi:10.1038/sj.npp.1301167. PMID 16880771.
  7. ^ http://www.medscape.com/viewarticle/554347?sssdmh=dm1.259053&src=ddd


v • d • e
Ergolines
Lysergic acid derivativesArgyreia nervosa, Rivea corymbosa
v • d • e
Anti-parkinson drugs: Budipine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pergolide". A list of authors is available in Wikipedia.