Pinacol coupling reaction



 A pinacol coupling reaction is an Wilhelm Rudolph Fittig in 1859.

Reaction mechanism

The first step in the alkene.

Scope

The Pinacol coupling of HMPA [4].


Two examples of pinacol coupling used in Nicolaou Taxol total synthesis.

References

  1. ^  R. Fittig. Justus Liebigs Ann. Chem. 110, 23–45 (1859).
  2. ^  Vanadium-Catalyzed Pinacol Coupling Reaction in Water Xiaoliang Xu and Toshikazu Hirao J. Org. Chem.; 2005; 70(21) pp 8594 - 8596 doi:10.1021/jo051213f
  3. ^  Pinacolization of aromatic aldehydes using Zn/montmorillonite K10-ZnCl2 in aqueous THF under ultrasound Zang Hongjun, Li Jitai, Bian Yanjiang, Li Tongshuang Chemical Journal on Internet Jan. 1, 2003 Vol.5 No.1 Online Article
  4. ^  Asymmetric synthesis by stereocontrol Yong Hae Kim, Sam Min Kim, and So Won Youn Pure Appl. Chem., Vol. 73, No. 2, pp. 283–286, 2001. Online Article
 
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