Pleconaril



Pleconaril
Systematic (IUPAC) name
3-{3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]
phenyl}-5-(trifluoromethyl)-1,2,4-oxadiazole
Identifiers
CAS number 153168-05-09
ATC code J05AX06
PubChem 1684
Chemical data
O3 
Mol. mass 381.35 g/mol
SMILES search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability 70% (oral)
Protein binding >99%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Oral, intranasal

Pleconaril is an antiviral drug being developed by bioavailable, and is active against viruses in the Picornaviridae family, including Enterovirus[2] and Rhinovirus.[3]

History

Pleconaril was originally developed by clinical trials.[1]

Mechanism of action

Pleconaril binds to a RNA, and in rhinoviruses it also prevents the virus from attaching itself to the host cell.[4]

References

  1. ^ a b Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus Exposure (Study P04295AM2). ClinicalTrials.gov. U.S. National Institutes of Health (March 2007). Retrieved on 2007-04-10.
  2. ^ Pevear D, Tull T, Seipel M, Groarke J (1999). "Activity of pleconaril against enteroviruses". Antimicrob Agents Chemother 43 (9): 2109–15. PMID 10471549.
  3. ^ Ronald B. Turner, J. Owen Hendley (2005). "Virucidal hand treatments for prevention of rhinovirus infection". J Antimicrob Chemother 56 (5): 805-807. PMID 16159927.
  4. ^ Florea N, Maglio D, Nicolau D (2003). "Pleconaril, a novel antipicornaviral agent". Pharmacotherapy 23 (3): 339–48. PMID 12627933. Free full text with registration
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Antivirals, other than for HIV (primarily Arbidol

Rimantadine)

neuraminidase inhibitors (FDA approved.
 
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