Prokinetic



Definition

Prokinetics are a class of drugs used on the digestive system. It includes all drugs whose primary effect is to augment the speed of intestinal transit, by increasing the frequency of contractions in the small intestine or making them stronger, but without disrupting their rhythm. They are mostly used to treat or prevent pathological gastroesophageal reflux, or to speed up absorption of certain other drugs. Some of them can also be used to help in the treatment of nausea or other symptoms associated with dyspepsia. Most of these drugs are grouped under ATC code A03F.

Pharmacokinetics

Both serotonin receptor modulators.

Cisapride acts on prolonged QT interval in ECG and serious cardiac arrythmia.

bethanechol. They increase motility and secretions as well as motilin like agents e.g. erythromycin.

Examples

Examples of this class of drug are:

Further reading

  • Hardman JG, Limbird LE, Gilman AG. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York: McGraw-Hill, 2001. ISBN 0-07-135469-7.
v • d • e
Drugs for functional gastrointestinal disorders (Propantheline

papaverine and derivatives: Drotaverine - Moxaverine

acting on Tegaserod)

other: Clebopride
 
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