SLUD

SLUDGE (Salivation, Lacrimation, Urination, Defecation Gastrointestinal upset: emesis] is a syndrome of pathological effects indicative of massive discharge of the parasympathetic nervous system. Unlikely to occur naturally, SLUD is usually encountered only in cases of drug overdose or exposure to cholinergic synapses throughout the body, thus chronically stimulating acetylcholine receptors throughout the body. The symptoms of "SLUDGE" are due to chronic stimulation of muscarinic acetylcholine receptors, in organs and muscles innervated by the parasympathetic nervous system:

• Salivation: stimulation of the salivary glands
• Lacrimation: stimulation of the lacrimal glands
• Urination: relaxation of the internal urinary sphincter, and contraction of the detrusor muscles
• Defecation: relaxation of the internal anal sphincter
• Gastrointestinal upset: Smooth muscle tone changes causing gastrointestianal problems
• Emesis: stimulation of the emesis center in the brainstem