Sevelamer



Sevelamer
Systematic (IUPAC) name
poly(allylamine-
co-N,N'-diallyl-1,3-diamino-2-hydroxypropane)
Identifiers
CAS number 52757-95-6
ATC code V03AE02
PubChem 3085017
DrugBank APRD01226
Chemical data
Formula [(C3H7N)a+b.(C9H17N2O)c]m
where a+b:c = 9:1
Mol. mass variable
Pharmacokinetic data
Bioavailability nil
Metabolism nil
Half life n/a
Excretion faecal 100%
Therapeutic considerations
Pregnancy cat.

B3 (Australia)

Legal status

Schedule 4 (Australia)

Routes oral

Sevelamer (phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. When taken with meals, sevelamer binds to dietary phosphate and prevents its absorption. It is marketed by Genzyme under the trade name Renagel.

Chemistry and pharmacology

Sevelamer is a copolymer of 2-(chloromethyl)oxirane (hydrogen bonding.

Clinical use

Indications

Sevelamer is indicated for the management of hyperphosphataemia in adult patients with stage 4 and 5 chronic renal failure (end stage renal disease).

Contraindications

Sevelamer therapy is contraindicated in hypophosphataemia or bowel obstruction.

Adverse effects

Common adverse drug reactions (ADRs) associated with the use of sevelamer include: hypotension, hypertension, nausea and vomiting, dyspepsia, diarrhea, flatulence, and/or constipation.

 
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