Ticlopidine



Ticlopidine
Systematic (IUPAC) name
3-[(2-chlorophenyl)methyl] -7-thia-3-azabicyclo[4.3.0] nona-8,10-diene
Identifiers
CAS number 55142-85-3
ATC code B01AC05
PubChem 5472
DrugBank APRD01257
Chemical data
S 
Mol. mass 263.786 g/mol
Pharmacokinetic data
Bioavailability >80%
Protein binding 98%
Metabolism Hepatic
Half life
  • 12 hours (single dose)
  • 4 to 5 days (after repeated dosing)
Excretion Renal and fecal
Therapeutic considerations
Pregnancy cat.

B1(AU) C(US)

Legal status
Routes Oral

Ticlopidine (trade name Ticlid) is an clopidogrel, which is felt to have a much lower hematologic risk. The usual dose is 250mg twice daily by the oral route.

Action

  • Inihibits platelet aggregation by altering the function of platelet membranes.
  • Prolongs bleeding time.
  • Decreased incidence of stroke in high-risk patients.

Contraindications

  • Hypersensitivity
  • Bleeding disorders
  • Active bleeding
  • Severe liver disease

Precautions

  • Risk of bleeding (trauma, surgery, history of peptic ulcer disease)
  • Renal or hepatic impairment
  • Geriatric patients (increased sensitivity)
  • Pregnancy, lactation, or children under 18
v • d • e
Antithrombotics (EDTA • Oxalate