Torasemide


Torasemide
Systematic (IUPAC) name
1-[4-(3-methylphenyl) aminopyridin-3-yl] sulfonyl-3-propan-2-yl-urea
Identifiers
CAS number	56211-40-6
ATC code	C03CA04
PubChem	41781
DrugBank	APRD00217
Chemical data
S
Mol. mass	348.421 g/mol
SMILES	search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Half life	3.5 hours; Cirrhosis: 7-8 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	Oral, IV

Torasemide (loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex.

Compared to other loop diuretics, torasemide has a more prolonged potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans (Dunn et al., 1995).

References

Dunn CJ, Fitton A, Brogden RN. Torasemide. An update of its pharmacological properties and therapeutic efficacy. Drugs. 1995 Jan;49(1):121-42. PMID 7705212

v • d • e Canrenone)

Categories: Sulfonylureas

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Torasemide". A list of authors is available in Wikipedia.