Triamterene



Triamterene
Systematic (IUPAC) name
6-phenylpteridine-2,4,7-triamine
Identifiers
CAS number 396-01-0
ATC code C03DB02
PubChem 5546
DrugBank APRD00079
Chemical data
N7 
Mol. mass 253.263 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 97%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Triamterene (trade name Dyrenium) is a salt substitute very cautiously.[1]

Mode of action

Triamterene directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule. Other diuretics cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more potassium out of the principal cell and into the forming urine. Blocking ENaC prevents this from happening. Amiloride works in the same way.

Side effects

Common calcium oxalate stones.

References

  1. ^ LoSalt Advisory Statement (PDF)
v • d • e
Canrenone)
 
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