UGT2B7



UDP glucuronosyltransferase 2 family, polypeptide B7
Identifiers
Symbol UGT2B7
Entrez 7364
HUGO 12554
OMIM 600068
RefSeq NM_001074
UniProt P16662
Other data
Locus Chr. 4 q13

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

This enzyme is located on the endoplasmic reticulum and nuclear membranes of cells. Its function is to glucuronic acid, using uridine diphosphate glucuronic acid.

UGT2B7 is the major enzyme isoform for the metabolism of morphine-6-glucuronide (M6G).[1]

References

  1. ^ Coffman B, Rios G, King C, Tephly T (1997). "Human UGT2B7 catalyzes morphine glucuronidation". Drug Metab. Dispos. 25 (1): 1-4. PMID 9010622.
 
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