Lisinopril



Lisinopril
Systematic (IUPAC) name
1-[6-amino-2- (1-carboxy-3-phenyl-propyl) amino-hexanoyl]pyrrolidine- 2-carboxylic acid dihydrate
Identifiers
CAS number 83915-83-7
ATC code C09AA03
PubChem 5362119
DrugBank APRD00560
Chemical data
O5 
Mol. mass 405.488 g/mol
Pharmacokinetic data
Bioavailability approx. 25%, but wide range between individuals (6 to 60%)
Protein binding 0
Metabolism None
Half life 12 hours
Excretion Eliminated unchanged in Urine
Therapeutic considerations
Pregnancy cat.

D - teratogenic

Legal status

℞ Prescription only

Routes  ?

Lisinopril (lye-SIN-o-pril) is a drug of the diabetes.

Historically, lisinopril was the third ACE inhibitor, after metabolized by the liver.

Pharmacology

Lisinopril is the overdosage, it can be removed from circulation by dialysis.

Clinical use

Its indications, contraindications and side effects are as those for all compliance. The usual daily dose in all indications ranges from 2.5mg in sensitive patients to 40mg. Some patients have been treated with 80mg daily and have tolerated this high dose well. Lower dosages must be used in patients with higher grade renal impairment (glomerular filtration rate (GFR) lower than 30ml/min).

History/brand names

Lisinopril was developed by AstraZeneca as Zestril®. In Australia it is marketed by AlphaPharm as Lisodur®.

References

  • Bussien JP, Waeber B, Nussberger J, Gomez HJ, Brunner HR. Once-daily lisinopril in hypertensive patients: Effect on blood pressure and the renin-angiotensin system. Curr Therap Res 1985;37:342-51.
  • Lisinopril info - rx-list.com
  • Goodman & Gilman's : The pharmacological basis of therapeutics, 10th. ed., 2001
  • Lisinopril.com - Lisinopril information


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Agents acting on the renin-angiotensin system (Aliskiren • Remikiren
 
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