Bremelanotide



Bremelanotide
Systematic (IUPAC) name
(3R,6R,9S,12R,15R,23R)-15-{[(2R)-2-

Acetamidohexanoyl]amino}-9-benzyl- 6-(3-carbamimidamidopropyl)-12- (1H-imidazol-5-ylmethyl)-3-(1H-indol- 3-ylmethyl)-2,5,8,11,14,17-hexaoxo- 1,4,7,10,13,18-hexaazacyclotricosane -23-carboxylic acid

Identifiers
CAS number 189691-06-3
ATC code  ?
PubChem None
Chemical data
O10 
Mol. mass 1025.2
SMILES search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

?(US)

Routes  ?

Bremelanotide (formerly PT-141) is the generic term for a new medication for use in treating sexual dysfunction in men (erectile dysfunction or impotence) as well as sexual dysfunction in women (sexual arousal disorder). It is the only known sexual desire. Bremelanotide is a spray introduced nasally.

Development

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Originally, the Melanotan II that bremelanotide was developed from was tested as a sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects.[1] In clinical studies, bremelanotide has been shown to be effective in treating male sexual and erectile dysfunction as well as female sexual dysfunction. It is currently being tested by Palatin Technologies.

A clinical trial was scheduled to begin in the first half of 2007, but was delayed until August 2007. On August 30th, Palatin announced that the FDA had expressed serious concerns regarding the benefit/risk ratio of bremelanotide with regards to the side effect of increased blood pressure. The FDA also stated that they would consider alternate uses for bremelanotide, including as a treatment for individuals who do not respond to more established ED treatments.

Structure

Bremelanotide is a cyclic hepta-function. Its molecular formula is C50H68N14O10 with a molecular weight of 1025.2.

References

  1. ^ Tanning drug may find new life as Viagra alternative (HTML). CNN (1999). Retrieved on 2007-09-16.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bremelanotide". A list of authors is available in Wikipedia.