Melanotan



Note: this article describes both melanotan and melanotan II: although their names are similar, they have different chemical and biological properties.

Melanotan 1 and melanotan II are both libido.

Historical development

Both drugs were developed at the University of Arizona. Researchers there knew that one of the best defenses against skin cancer was a natural tan which has been slowly developed over weeks. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural tanning system to produce a protective tan prior to UV exposure. They knew the body's naturally occurring hormone alpha-melanocyte stimulating hormone (α-MSH) caused melanogenesis, a process by which the skin's tanning cells (melanocytes) produce the skin's tanning pigment (melanin). With that knowledge they tested to see if administering this hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural alpha-MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent and stable alternative, one that would be more practical.

After synthesizing and screening hundreds of molecules, the researchers headed by Dr. Victor Hruby, found a UV radiation [2]. This in turn will reduce the potential for skin damage that can eventually lead to skin cancer.

Peptide properties

Melanotan 1

Melanotan 1
Other names Melanotan
Identifiers
CAS number 75921-69-6
MeSH Melanotan-1
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Melanotan 1 has the amino acid sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 or [Nle4, D-Phe7]-alpha-MSH.

Melanotan is currently being tested and developed under the name CUV1647 by the Australian company Clinuvel Pharmaceuticals, for indications such as polymorphous light eruption (PMLE) and actinic keratosis (AK).

Melanotan II

Melanotan II
Identifiers
CAS number 121062-08-6
PubChem 92432
MeSH melanotan-II
Properties
Molecular formula C50H69N15O9
Molar mass 1024.180
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Melanotan II has aphrodisiac properties.[citation needed]

It is a cyclic lactam analog of alpha-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.

Bremelanotide

Main article: Bremelanotide

Palatin Technologies of New Jersey has developed another hormone targeted towards sexual dysfunction based upon melanotan II called bremelanotide (formerly called PT-141).

Bremelanotide is a clinical trials to treat erectile dysfunction and sexual arousal disorder.

References

  1. ^ UA-developed synthetic hormones speed a tan (HTML). Arizona Daily Star (2006). Retrieved on 2007-09-22.
  2. ^ The Barbie Drug (HTML,WMV). Campbell Live, TV3 (2007). Retrieved on 2007-09-16.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Melanotan". A list of authors is available in Wikipedia.