Propofol

Propofol is a short-acting analgesia.^[1]

Propofol is approved for the induction and maintenance of anesthesia in more than 50 countries.

It is also commonly used in veterinary medicine and many veterinary anaesthetists regard it as the induction agent of choice for small animals (dogs, cats etc) as it can be administered to effect, reducing the risk of accidental overdose.

Chemistry

Propofol is a water-immiscible oil and so cannot be injected per se. Originally developed by ICI (Imperial Chemical Industries) as ICI 35868, initial clinical trials followed in 1977 in a form solubilised in benzyl alcohol. Propofol emulsion appears as a highly opaque white fluid due to the scattering of light from the tiny (~150 nm) oil droplets that it contains.

A water soluble form of the drug, propofol phosphate, has recently been developed and tested in animals with positive results, being rapidly broken down once in the body to form propofol. This new formulation might well have superior properties for use in humans such as being more readily injectable and perhaps without the pain at injection site that often occurs with the traditional form of the drug.^[2] Fospropofol disodium is rapidly converted into propofol by the enzyme alkaline phosphatase, and is now being developed for human use under the brand name Aquavan.[1]

Pharmacology

Propofol is highly protein bound in vivo and is metabolised by conjugation in the liver. Its rate of clearance exceeds hepatic blood flow, suggesting an extrahepatic site of elimination as well. Its mechanism of action is uncertain, but it is postulated that its primary effect may be potentiation of the GABA-A receptor, possibly by slowing the channel closing time. Recent research has also suggested the endocannabinoid system may contribute significantly to Propofol's anesthetic action and to its unique properties.^[3]

The elimination half-life of propofol has been estimated to be between 2–24 hours. However, its duration of clinical effect is much shorter because propofol is rapidly distributed into peripheral tissues. When used for IV sedation propofol typically wears off in minutes. Propofol is versatile; the drug can be given for short or prolonged sedation as well as for general anesthesia. Its use is not associated with nausea as opposed to opiod medications. These characteristics of rapid onset and recovery along with its amnestic effects have led to its widespread use for sedation and anesthesia.

Side effects

Aside from the hypotension (mainly through vasodilatation) and transient apnea following induction doses, one of propofol's most frequent side effects is pain on injection, especially in smaller veins. This pain can be mitigated by pretreatment with malignant hyperpyrexia.

Another recently described rare, but serious, side effect is propofol infusion syndrome. This potentially lethal metabolic derangement has been reported in critically-ill patients after a prolonged infusion of high-dose propofol in combination with corticosteroids.^[5]

Abuse of propofol as a recreational drug has been reported, usually among medical staff such as anaesthesiologists who have access to the drug. Despite a lack of analgesic properties, propofol's sedative action presumably produces euphoric effects. The steep dose response curve of the drug makes such abuse very dangerous without proper monitoring, and several deaths have been recorded.^[6][7]

References

1. ^ Miner JR, Burton JH. Clinical practice advisory: Emergency department procedural sedation with propofol. Annals of Emergency Medicine. 2007 Aug;50(2):182-7, 187.e1. Epub 2007 Feb 23.
2. ^ Banaszczyk MG, Carlo AT, Millan V, Lindsey A, Moss R, Carlo DJ, Hendler SS. Propofol phosphate, a water-soluble propofol prodrug: in vivo evaluation. Anesthesia and Analgesia. 2002 Nov;95(5):1285-92
3. ^ Fowler, CJ. "Possible involvement of the endocannabinoid system in the actions of three clinically used drugs." Trends Pharmacol. Sci. 2004 Feb;25(2):59-61.
4. ^ Propofol Drug Information,Professional. drugs.com. Retrieved on 2007-01-02.
5. ^ Vasile B, Rasulo F, Candiani A, Latronico N (2003). "The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome". Intensive care medicine 29 (9): 1417-25. doi:10.1007/s00134-003-1905-x. PMID 12904852.
6. ^ Iwersen-Bergmann S, Rösner P, Kühnau HC, Junge M, Schmoldt A. Death after excessive propofol abuse. International Journal of Legal Medicine. 2001;114(4-5):248-51.
7. ^ Kranioti EF, Mavroforou A, Mylonakis P, Michalodimitrakis M. Lethal self administration of propofol (Diprivan). A case report and review of the literature. Forensic Science International. 2007 Mar 22;167(1):56-8. Epub 2006 Jan 23.