Dizocilpine

Dizocilpine, also known as MK-801, is a non-competitive calcium (Ca²⁺) through the channel. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it. The drug is an anti-convulsant.

Possible future medical uses

The effects of MK-801 at NMDA receptors are clear and significant. NMDA receptors are key in the progression of Merck, a drug company, promptly dropped development of MK-801.

Recreational use

Dizocilpine may be effective as a recreational drug, and may have an active dose in the 50-100μg range. Little is known in this context about its effects, dosage, and risks. Dizocilpine's high potency makes its dosage more difficult to accurately control when compared to other similar drugs. As a result, the chances of phencyclidine (PCP), and causes far worse amnesia and residual deficits in thinking, which have hindered its acceptance as a recreational drug.^{[citation needed]}

References

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2. ^ Kocaeli H, Korfali E, Ozturk H, Kahveci N, Yilmazlar S. 2005. MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats. Surgical Neurology. Volume 64, Supplement 2, Pages S22-S26; discussion S27. Accessed January 7, 2007.
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