Methoxyflurane



Methoxyflurane
Systematic (IUPAC) name
2,2-dichloro-1,1-difluoro-1-methoxy-ethane
Identifiers
CAS number 76-38-0
ATC code N01AB03
PubChem 4116
DrugBank APRD00744
Chemical data
O 
Mol. mass 164.965 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Inhalation

Methoxyflurane (C3H4Cl2F2O) is an fluoride ions being produced by its metabolism in the kidney. Its minimum alveolar concentration (MAC) is 0.2, hence it is extremely potent. It has a high lipid solubility (oil:gas coefficient around 950) giving it a very slow onset/offset, thus undesirable for anesthetic purposes.

Methoxyflurane is used extensively in Australian ambulance services, and in St John Ambulance as an emergency analgesic.

v • d • e
Anesthetic: General anesthetics (Xenon
 
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