Nordazepam



Nordazepam
Systematic (IUPAC) name
9-chloro-6-phenyl-
2,5-diazabicyclo[5.4.0]undeca-
5,8,10,12-tetraen-3-one
Identifiers
CAS number 1088-11-5
ATC code N05BA16
PubChem 2997
DrugBank none
Chemical data
O 
Mol. mass 270.71
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 50-120 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule IV(US)

Routes Oral

Nordazepam (marketed under brand names Stilny®, Madar®, Vegesan®, and Calmday®), also known as nordiazepam and desmethyldiazepam, is a medazepam.[1]

Side effects

Common side effects of nordazepam include somnolence, which is more common in elderly patients and/or people on high dose regimens. Hypotonia, which is much less common, is also associated with high doses and/or old age.

Interactions

Benzodiazepines including N-desmethyldiazepam (nordazepam) may inhibit the glucuronidation of morphine leading to increased levels of and prolongation of the effects of morphine.[2]

Abuse

Nordazepam and other sedative hypnotic drugs are detected frequently in cases of people suspected of driving under the influence of drugs. Other benzodiazepines and zopiclone.[3]

References

  1. ^ Biam. NORDAZEPAM (French). Retrieved on 18 October, 2005.
  2. ^ Pacifici GM; Gustafsson LL, Säwe J, Rane A. (Apr 1986). "Metabolic interaction between morphine and various benzodiazepines.". Acta Pharmacol Toxicol (Copenh). 58 (4): 249-52. PMID 2872767.
  3. ^ Jones AW; Holmgren A, Kugelberg FC. (Apr 2007). "Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results.". Ther Drug Monit. 29 (2): 248-60. PMID 17417081.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nordazepam". A list of authors is available in Wikipedia.