RNase H

The ion.

Members of the RNase H family can be found in nearly all organisms, from archaea and prokaryota to eukaryota. In eukaryotic DNA replication, RNase H is responsible for cutting out the RNA primer, allowing completion of the newly synthesized DNA.

Retroviral RNase H, a part of the viral aptamers are in the preclinical stage.

In a molecular biology laboratory, as RNase H specifically degrades the RNA in RNA:DNA hybrids and will not degrade DNA or unhybridized RNA, it is commonly used to destroy the RNA template after first-strand EDTA, is often added to sequester the required metal ions in the reaction mixture.