Hexobarbital



Hexobarbital
Systematic (IUPAC) name
5-(1-cyclohexenyl)- 1,5-dimethyl- hexahydropyrimidine- 2,4,6-trione
Identifiers
CAS number 56-29-1
ATC code N05CA16
PubChem 3608
DrugBank EXPT03301
Chemical data
O3 
Mol. mass 236.267 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 25%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Hexobarbital is a thiopental would be the barbiturate of choice for this application these days. Hexobarbital was also marketed as a rapid-acting sleeping pill with short duration (tradenames: Citopan, Evipan and others, usually in 250 mg strength tablets). Hexobarbital is still used in some scientific research.

Further reading

  • Takenoshita R, Toki S (2004). "[New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]". Yakugaku Zasshi 124 (12): 857-71. PMID 15577260.
  • Wahlström G (1998). "A study of the duration of acute tolerance induced with hexobarbital in male rats.". Pharmacol Biochem Behav 59 (4): 945-8. PMID 9586853.
  • Korkmaz S, Ljungblad E, Wahlström G (1995). "Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat.". Brain Res 676 (2): 371-7. PMID 7614008.
  • Dall V, Orntoft U, Schmidt A, Nordholm L (1993). "Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital.". Pharmacol Biochem Behav 46 (1): 73-6. PMID 8255925.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hexobarbital". A list of authors is available in Wikipedia.