Fencamfamine



Fencamfamine
Systematic (IUPAC) name
N-ethyl-3-phenyl-norbornan-2-amine
Identifiers
CAS number 2240-14-4
ATC code N06BA06
PubChem 14584
Chemical data
N 
Mol. mass  ?
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule IV (USA)

Routes  ?

Fencamfamine (marketed under the trade names Glucoenergan, Reactivan) is a dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases.[1]

Pharmacology

Fencamfamine acts as an indirect naloxone.[3]

Side effects

Side effects include: dry mouth, loss of appetite, restlessness and tremor.

Contraindications

Contraindications: should not be used in patients with heart disease, angina, glaucoma, thyrotoxicosis or in patients being treated with monoamine oxidase inhibitors.

References

  1. ^ http://home.intekom.com/pharm/merckp/reactivn.html
  2. ^ Seyfried CA. Dopamine uptake inhibiting versus dopamine releasing properties of fencamfamine: an in vitro study. Biochemical Pharmacology. 1983 Aug 1;32(15):2329-31.
  3. ^ Planeta Cda S, Aizenstein ML, DeLucia R. Reinforcing properties of fencamfamine: involvement of dopamine and opioid receptors. Pharmacology, Biochemistry and Behavior. 1995 Jan;50(1):35-40.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Fencamfamine". A list of authors is available in Wikipedia.