Lisdexamfetamine

Lisdexamfetamine (L-lysine-d-amphetamine) is a L-lysine. Lisdexamfetamine was developed so that the psychostimulant is released and activated more slowly as the prodrug molecule is hydrolyzed—consequently cleaving off the amino acid-during the first pass through the intestines and/or the liver.

Vyvanse is the dimesylate salt of lisdexamfetamine marketed by pharmaceutical market share. Shire will be applying for FDA—as well as European—approval for the treatment of adolescents and adult patients with ADHD. Shire has stated prospects of applying Vyvanse for FDA approval for the treatment of depression.

A 25 mg strength Vyvanse capsule is molecularly equivalent to 10 mg Dexedrine Spansules (both the aforementioned pharmaceuticals are about 7.425 mg dextroamphetamine). 30mg is the weakest Vyvanse available (edit.) However, this molecular equivalence is not a AUC for the aforementioned pharmaceuticals is equivalent, the peak exposure of dextroamphetamine with Vyvanse is about 50% higher than that of dexedrine with Dexedrine Spansules.^[1]

In human oral abuse-liability studies, 150 mg Vyvanse produced a "likeability"—euphoric effect—that was determined to be indistinguishable from 200 mg of the Schedule IV drug diethylpropion hydrochloride or 40 mg of dextroamphetamine.^[2]  

Notes and references

1. ^ FDA Approval of Vyvanse - Pharmacological Reviews
2. ^ http://www.vyvanse.com/pdf/prescribing_information.pdf

http://www.vyvanse.com

erk wann