Indatraline


Indatraline
Systematic (IUPAC) name
(1R,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine
Identifiers
CAS number	86939-10-8
ATC code	?
PubChem	126280
Chemical data
N
Mol. mass	292.202 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Indatraline, also known as Lu 19-005, is a nonselective serotonin with effects similar to those of cocaine. However, the effects have been shown to have slower onset and longer duration than cocaine, suggesting that the compound may, along with similar compounds, be used for treatment of cocaine abuse.^[1] Research has also suggested that indatraline can be used to block the action of methamphetamine.^[2]

For a more detailed discussion of indatraline pharmacology, see Indatraline pharmacology

References

^ Negus SS, Brandt MR, Mello NK. "Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys." J Pharmacol Exp Ther (1999) 291(1):60-9.[1]
^ Rothman, B. R. eta al, "Neurochemical Neutralization of Methamphetamine With High-Affinity Nonselective Inhibitors of Biogenic Amine Transporters: A Pharmacological Strategy for Treating Stimulant Abuse." Synapse (2000) 35:222-227.[2]

Theophylline
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Piperazines	BZP • MeOPP • MBZP • mCPP • 2C-B-BZP
Tropanes	Brasofensine • CFT • Cocaethylene • Cocaine • Lometopane • RTI-121 • Tesofensine • Troparil
Thujone
Phenylaminooxazoles	4-Methyl-aminorex • Aminorex • Clominorex • Fenozolone • Fluminorex • Pemoline • Thozalinone
Others	Amineptine • Bemegride • BPAP • Clenbuterol • Clofenciclan • Cyclopentamine • Cyprodenate • Desoxypipradrol • Ethylphenidate • Ethamivan • Gilutensin • GYKI-52895 • Hexacyclonate • Indanorex • Indatraline • Isometheptene • Mazindol • MDPV • Mesocarb • Dexmethylphenidate) • Naphthylisopropylamine • Nikethamide • Nocaine • Nomifensine • Phacetoperane • Phthalimidopropiophenone • Pipradrol • Prolintane • Propylhexedrine • Pyrovalerone • Sibutramine • Tuamine • Vanoxerine • Yohimbine • Zylofuramine
See also Sympathomimetic amines

Categories: Dopamine reuptake inhibitors

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Indatraline". A list of authors is available in Wikipedia.